FFPE tissue may not be suitable for analysis native proteins, and generally is inferior for the types of genetic analysis, such as PCR, qPCR, or next generation DNA sequencing, that are becoming commonplace. Frozen tissue, on the other hand, preserves the DNA, RNA, and native proteins. However, frozen tissue archives can be quickly lost due to carelessness in the lab. Frozen tissues are also less familiar to pathologists, who are generally more comfortable making diagnoses after microscopic analysis of FFPE tissue.