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Our Publications

Published

Tumor-specific activation of folate receptor beta enables reprogramming of immune cells in the tumor microenvironment

Zhang, F., Huang, B., Utturkar, S. M., Luo, W., Cresswell, G., Herr, S. A., ... & Low, P. S. (2024). Tumor-specific activation of folate receptor beta enables reprogramming of immune cells in the tumor microenvironment. Frontiers in Immunology, 15, 1354735.

Published

Bifunctional Tumor-Targeted Bioprobe for Phothotheranosis

Park, H. S., Yokomizo, S., Wang, H., Manganiello, S., Monaco, H., McDonnell, R., ... & Choi, H. S. (2024). Bifunctional tumor-targeted bioprobe for phothotheranosis. Biomaterials Research, 28, 0002.

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An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis

Au, K. M., Wilson, J. E., Ting, J. P. Y., & Wang, A. Z. (2023). An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis. Nature Biomedical Engineering, 1-23.

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The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

Anerillas, C., Mazan-Mamczarz, K., Herman, A. B., Munk, R., Lam, K. W. G., Calvo-Rubio, M., ... & Gorospe, M. (2023). The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress. Nature Aging, 3(10), 1237-1250.

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Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells

He, S., Lei, P., Kang, W., Cheung, P., Xu, T., Mana, M., ... & Saeidi, N. (2023). Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells. Gastroenterology, 164(7), 1137-1151.

Published

Astrocytic deletion of protein kinase R‐like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke

Lahiri, A., Walton, J. C., Zhang, N., Billington, N., DeVries, A. C., & Meares, G. P. (2023). Astrocytic deletion of protein kinase r‐like <scp>er</scp> kinase (<scp>perk</scp>) does not affect learning and memory in aged mice but worsens outcome from experimental stroke. Journal of Neuroscience Research, 101(10), 1586–1610. https://doi.org/10.1002/jnr.25224

Published

BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma

Kurata, K., Samur, M. K., Liow, P., Wen, K., Yamamoto, L., Liu, J., ... & Anderson, K. C. (2023). BRD9 degradation disrupts ribosome biogenesis in multiple myeloma. Clinical Cancer Research, 29(9), 1807-1821.

Published

An aptamer-based depot system for sustained release of small molecule therapeutics

Wang, D., Li, Y., Deng, X., Torre, M., Zhang, Z., Li, X., Zhang, W., Cullion, K., Kohane, D. S., & Weldon, C. B. (2023). An aptamer-based depot system for sustained release of Small Molecule Therapeutics. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37002-0

Published

Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms

Jimenez-Rondan, F. R., Ruggiero, C. H., McKinley, K. L., Koh, J., Roberts, J. F., Triplett, E. W., & Cousins, R. J. (2023). Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms. American Journal of Physiology-Gastrointestinal and Liver Physiology, 324(3), G159-G176.

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Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa

Mercau, M. E., Akalu, Y. T., Mazzoni, F., Gyimesi, G., Alberto, E. J., Kong, Y., ... & Ghosh, S. (2023). Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa. Science Advances, 9(3), eade9459.

Published

Enhancement of Trans-Tympanic Drug Delivery by Pharmacological Induction of Inflammation

Zhang, Z., Li, X., Yang, R., Cullion, K., Prugneau, L., & Kohane, D. S. (2023). Enhancement of Trans-Tympanic Drug Delivery by Pharmacological Induction of Inflammation. Molecular Pharmaceutics, 20(2), 1375-1381.

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GPR68 limits the severity of chemical-induced oral epithelial dysplasia

Shore, D., Griggs, N., Graffeo, V., Amin, A. R., Zha, X.-ming, Xu, Y., & McAleer, J. P. (2023). GPR68 limits the severity of chemical-induced oral epithelial dysplasia. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-27546-y

Published

Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA)

Benchama, O., Malamas, M. S., Praveen, K., Ethier, E. C., Williams, M. K., Makriyannis, A., & Avraham, H. K. (2022). Inhibition of triple negative breast cancer-associated inflammation and progression by n- acylethanolamine acid amide hydrolase (NAAA). Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-26564-6

Published

Enhancement of Trans-Tympanic Drug Delivery by Pharmacological
Induction of Inflammation

Lahiri, A., Walton, J. C., Zhang, N., Billington, N., DeVries, A. C., & Meares, G. P. (2023). Astrocytic deletion of protein kinase r‐like <scp>er</scp> kinase (<scp>perk</scp>) does not affect learning and memory in aged mice but worsens outcome from experimental stroke. Journal of Neuroscience Research, 101(10), 1586–1610. https://doi.org/10.1002/jnr.25224

Published

Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis

Zhou, Y., Hou, D., Marigo, C. C., Bonelli, J., Rocas, P., Cheng, F., Yang, X., Rocas, J., Hamberg, N. M., & Han, J. (2022). Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis. IScience, 25(11), 105390. https://doi.org/10.1016/j.isci.2022.105390

Published

mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome

Huang, Z., You, X., Chen, L., Du, Y., Brodeur, K., Jee, H., Wang, Q., Linder, G., Darbousset, R., Cunin, P., Chang, M. H., Wactor, A., Wauford, B. M., Todd, M. J., Wei, K., Li, Y., Levescot, A., Iwakura, Y., Pascual, V., … Lee, P. Y. (2022). MTORC1 links pathology in experimental models of still’s disease and macrophage activation syndrome. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-34480-6

Published

A BDNF-TrkB autocrine loop enhances senescent cell viability

Anerillas, C., Herman, A. B., Munk, R., Garrido, A., Lam, K.-W. G., Payea, M. J., Rossi, M., Tsitsipatis, D., Martindale, J. L., Piao, Y., Mazan-Mamczarz, K., Fan, J., Cui, C.-Y., De, S., Abdelmohsen, K., de Cabo, R., & Gorospe, M. (2022). A BDNF-TrkB autocrine loop enhances senescent cell viability. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33709-8

Published

Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition

Xu, L., Guo, J., Moledina, D. G., & Cantley, L. G. (2022). Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition. Nature communications, 13(1), 4892.

Published

Tissue-specific modifier alleles determine Mertk loss-of-function traits

Akalu, Y. T., Mercau, M. E., Ansems, M., Hughes, L. D., Nevin, J., Alberto, E. J., Liu, X. N., He, L.-Z., Alvarado, D., Keler, T., Kong, Y., Philbrick, W. M., Bosenberg, M., Finnemann, S. C., Iavarone, A., Lasorella, A., Rothlin, C. V., & Ghosh, S. (2022). Tissue-specific modifier alleles determine mertk loss-of-function traits. ELife, 11. https://doi.org/10.7554/elife.80530

Published

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3KmTOR inhibition

Fang, L., Ford-Roshon, D., Russo, M., O’Brien, C., Xiong, X., Gurjao, C., Grandclaudon, M., Raghavan, S., Corsello, S. M., Carr, S. A., Udeshi, N. D., Berstler, J., Sicinska, E., Ng, K., & Giannakis, M. (2022). RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mtor inhibition. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-30794-7

Published

Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response

Li, Wanjin, et al. “Nuclear Ripk1 Promotes Chromatin Remodeling to Mediate Inflammatory Response.” Cell Research, 2022, https://doi.org/10.1038/s41422-022-00673-3.

Published

EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

Wu, Q., Zhen, Y., Shi, L., Vu, P., Greninger, P., Adil, R., Merritt, J., Egan, R., Wu, M.J., Yin, X. and Ferrone, C.R., 2022. EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinomaCombination Treatment in FGFR2-Fusion Cholangiocarcinoma. Cancer Discovery.

Published

Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor

Wu, M.J., Shi, L., Dubrot, J., Merritt, J., Vijay, V., Wei, T.Y., Kessler, E., Olander, K.E., Adil, R., Pankaj, A. and Tummala, K.S., 2021. Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma. Cancer discovery.

Published

Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib

Han, H., Li, S., Chen, T., Fitzgerald, M., Liu, S., Peng, C., Tang, K.H., Cao, S., Chouitar, J., Wu, J. and Peng, D., 2021. Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib. Cancer research, 81(20), pp.5311-5324.

Published

Mobocertinib (TAK-788) A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non−Small Cell Lung Cancer

Gonzalvez, F., Vincent, S., Baker, T.E., Gould, A.E., Li, S., Wardwell, S.D., Nadworny, S., Ning, Y., Zhang, S., Huang, W.S. and Hu, Y., 2021. Mobocertinib (TAK-788): a targeted inhibitor of EGFR exon 20 insertion mutants in non–small cell lung cancer. Cancer discovery, 11(7), pp.1672-1687.

Published

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

Allouche, J., Rachmin, I., Adhikari, K., Pardo, L.M., Lee, J.H., McConnell, A.M., Kato, S., Fan, S., Kawakami, A., Suita, Y. and Wakamatsu, K., 2021. NNT mediates redox-dependent pigmentation via a UVB-and MITF-independent mechanism. Cell, 184(16), pp.4268-4283.

Published

Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy indiverse brain metastatic breast cancers

Kitamura, Y., Kanaya, N., Moleirinho, S., Du, W., Reinshagen, C., Attia, N., Bronisz, A., Revai Lechtich, E., Sasaki, H., Mora, J.L. and Brastianos, P.K., 2021. Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Science Advances, 7(10), p.eabe8671.

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