Our Clients' Publications
Published
Neoadjuvant CAN-2409 plus Prodrug in Combination with Standard of Care Chemoradiation for Borderline Resectable Pancreatic Adenocarcinoma
Nichols, W. G., Manzanera, A. G., Bloomston, M., Rosas‐Camargo, V., Melendez, F. D. H., Rao, S., … & Tak, P. P. (2024). Neoadjuvant can-2409 plus prodrug in combination with standard of care chemoradiation for borderline resectable pancreatic adenocarcinoma.. https://doi.org/10.21203/rs.3.rs-5183420/v1
Published
Unlocking the Potential: FKK6 as a Microbial Mimicry-Based Therapy for Chronic Inflammation-Associated Colorectal Cancer in a Murine Model
Lucia Sládeková, Hao Li, Vera M. DesMarais, Amanda P. Beck, Hillary Guzik, Barbora Vyhlídalová, Haiwei Gu, Sridhar Mani, Zdeněk Dvořák
bioRxiv 2024.07.30.605845; doi: https://doi.org/10.1101/2024.07.30.605845
Published
Tumor-specific activation of folate receptor beta enables reprogramming of immune cells in the tumor microenvironment
Zhang, F., Huang, B., Utturkar, S. M., Luo, W., Cresswell, G., Herr, S. A., ... & Low, P. S. (2024). Tumor-specific activation of folate receptor beta enables reprogramming of immune cells in the tumor microenvironment. Frontiers in Immunology, 15, 1354735.
Published
Bifunctional Tumor-Targeted Bioprobe for Phothotheranosis
Park, H. S., Yokomizo, S., Wang, H., Manganiello, S., Monaco, H., McDonnell, R., ... & Choi, H. S. (2024). Bifunctional tumor-targeted bioprobe for phothotheranosis. Biomaterials Research, 28, 0002.
Published
An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis
Au, K. M., Wilson, J. E., Ting, J. P. Y., & Wang, A. Z. (2023). An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis. Nature Biomedical Engineering, 1-23.
Published
The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress
Anerillas, C., Mazan-Mamczarz, K., Herman, A. B., Munk, R., Lam, K. W. G., Calvo-Rubio, M., ... & Gorospe, M. (2023). The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress. Nature Aging, 3(10), 1237-1250.
Published
Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells
He, S., Lei, P., Kang, W., Cheung, P., Xu, T., Mana, M., ... & Saeidi, N. (2023). Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells. Gastroenterology, 164(7), 1137-1151.
Published
Astrocytic deletion of protein kinase R‐like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke
Lahiri, A., Walton, J. C., Zhang, N., Billington, N., DeVries, A. C., & Meares, G. P. (2023). Astrocytic deletion of protein kinase r‐like <scp>er</scp> kinase (<scp>perk</scp>) does not affect learning and memory in aged mice but worsens outcome from experimental stroke. Journal of Neuroscience Research, 101(10), 1586–1610.
Published
BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma
Kurata, K., Samur, M. K., Liow, P., Wen, K., Yamamoto, L., Liu, J., ... & Anderson, K. C. (2023). BRD9 degradation disrupts ribosome biogenesis in multiple myeloma. Clinical Cancer Research, 29(9), 1807-1821.
Published
An aptamer-based depot system for sustained release of small molecule therapeutics
Wang, D., Li, Y., Deng, X., Torre, M., Zhang, Z., Li, X., Zhang, W., Cullion, K., Kohane, D. S., & Weldon, C. B. (2023). An aptamer-based depot system for sustained release of Small Molecule Therapeutics. Nature Communications, 14(1).
Published
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms
Jimenez-Rondan, F. R., Ruggiero, C. H., McKinley, K. L., Koh, J., Roberts, J. F., Triplett, E. W., & Cousins, R. J. (2023). Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms. American Journal of Physiology-Gastrointestinal and Liver Physiology, 324(3), G159-G176.
Published
Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa
Mercau, M. E., Akalu, Y. T., Mazzoni, F., Gyimesi, G., Alberto, E. J., Kong, Y., ... & Ghosh, S. (2023). Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa. Science Advances, 9(3), eade9459.
Published
Enhancement of Trans-Tympanic Drug Delivery by Pharmacological Induction of Inflammation
Zhang, Z., Li, X., Yang, R., Cullion, K., Prugneau, L., & Kohane, D. S. (2023). Enhancement of Trans-Tympanic Drug Delivery by Pharmacological Induction of Inflammation. Molecular Pharmaceutics, 20(2), 1375-1381.
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GPR68 limits the severity of chemical-induced oral epithelial dysplasia
Shore, D., Griggs, N., Graffeo, V., Amin, A. R., Zha, X.-ming, Xu, Y., & McAleer, J. P. (2023). GPR68 limits the severity of chemical-induced oral epithelial dysplasia. Scientific Reports, 13(1).
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Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA)
Benchama, O., Malamas, M. S., Praveen, K., Ethier, E. C., Williams, M. K., Makriyannis, A., & Avraham, H. K. (2022). Inhibition of triple negative breast cancer-associated inflammation and progression by n- acylethanolamine acid amide hydrolase (NAAA). Scientific Reports, 12(1).
Published
Enhancement of Trans-Tympanic Drug Delivery by Pharmacological
Induction of Inflammation
Lahiri, A., Walton, J. C., Zhang, N., Billington, N., DeVries, A. C., & Meares, G. P. (2023). Astrocytic deletion of protein kinase r‐like <scp>er</scp> kinase (<scp>perk</scp>) does not affect learning and memory in aged mice but worsens outcome from experimental stroke. Journal of Neuroscience Research, 101(10), 1586–1610.
Published
Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis
Zhou, Y., Hou, D., Marigo, C. C., Bonelli, J., Rocas, P., Cheng, F., Yang, X., Rocas, J., Hamberg, N. M., & Han, J. (2022). Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis. IScience, 25(11), 105390.
Published
mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
Huang, Z., You, X., Chen, L., Du, Y., Brodeur, K., Jee, H., Wang, Q., Linder, G., Darbousset, R., Cunin, P., Chang, M. H., Wactor, A., Wauford, B. M., Todd, M. J., Wei, K., Li, Y., Levescot, A., Iwakura, Y., Pascual, V., … Lee, P. Y. (2022). MTORC1 links pathology in experimental models of still’s disease and macrophage activation syndrome. Nature Communications, 13(1).
Published
A BDNF-TrkB autocrine loop enhances senescent cell viability
Anerillas, C., Herman, A. B., Munk, R., Garrido, A., Lam, K.-W. G., Payea, M. J., Rossi, M., Tsitsipatis, D., Martindale, J. L., Piao, Y., Mazan-Mamczarz, K., Fan, J., Cui, C.-Y., De, S., Abdelmohsen, K., de Cabo, R., & Gorospe, M. (2022). A BDNF-TrkB autocrine loop enhances senescent cell viability. Nature Communications, 13(1).
Published
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition
Xu, L., Guo, J., Moledina, D. G., & Cantley, L. G. (2022). Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition. Nature communications, 13(1), 4892.
Published
Tissue-specific modifier alleles determine Mertk loss-of-function traits
Akalu, Y. T., Mercau, M. E., Ansems, M., Hughes, L. D., Nevin, J., Alberto, E. J., Liu, X. N., He, L.-Z., Alvarado, D., Keler, T., Kong, Y., Philbrick, W. M., Bosenberg, M., Finnemann, S. C., Iavarone, A., Lasorella, A., Rothlin, C. V., & Ghosh, S. (2022). Tissue-specific modifier alleles determine mertk loss-of-function traits. ELife, 11.
Published
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3KmTOR inhibition
Fang, L., Ford-Roshon, D., Russo, M., O’Brien, C., Xiong, X., Gurjao, C., Grandclaudon, M., Raghavan, S., Corsello, S. M., Carr, S. A., Udeshi, N. D., Berstler, J., Sicinska, E., Ng, K., & Giannakis, M. (2022). RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mtor inhibition. Nature Communications, 13(1).
Published
Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response
Li, Wanjin, et al. “Nuclear Ripk1 Promotes Chromatin Remodeling to Mediate Inflammatory Response.” Cell Research, 2022,
Published
EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
Wu, Q., Zhen, Y., Shi, L., Vu, P., Greninger, P., Adil, R., Merritt, J., Egan, R., Wu, M.J., Yin, X. and Ferrone, C.R., 2022. EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinomaCombination Treatment in FGFR2-Fusion Cholangiocarcinoma. Cancer Discovery.
Published
Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor
Wu, M.J., Shi, L., Dubrot, J., Merritt, J., Vijay, V., Wei, T.Y., Kessler, E., Olander, K.E., Adil, R., Pankaj, A. and Tummala, K.S., 2021. Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma. Cancer discovery.
Published
Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib
Han, H., Li, S., Chen, T., Fitzgerald, M., Liu, S., Peng, C., Tang, K.H., Cao, S., Chouitar, J., Wu, J. and Peng, D., 2021. Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib. Cancer research, 81(20), pp.5311-5324.
Published
Mobocertinib (TAK-788) A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non−Small Cell Lung Cancer
Gonzalvez, F., Vincent, S., Baker, T.E., Gould, A.E., Li, S., Wardwell, S.D., Nadworny, S., Ning, Y., Zhang, S., Huang, W.S. and Hu, Y., 2021. Mobocertinib (TAK-788): a targeted inhibitor of EGFR exon 20 insertion mutants in non–small cell lung cancer. Cancer discovery, 11(7), pp.1672-1687.
Published
NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism
Allouche, J., Rachmin, I., Adhikari, K., Pardo, L.M., Lee, J.H., McConnell, A.M., Kato, S., Fan, S., Kawakami, A., Suita, Y. and Wakamatsu, K., 2021. NNT mediates redox-dependent pigmentation via a UVB-and MITF-independent mechanism. Cell, 184(16), pp.4268-4283.
Published
Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy indiverse brain metastatic breast cancers
Kitamura, Y., Kanaya, N., Moleirinho, S., Du, W., Reinshagen, C., Attia, N., Bronisz, A., Revai Lechtich, E., Sasaki, H., Mora, J.L. and Brastianos, P.K., 2021. Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Science Advances, 7(10), p.eabe8671.