Profile the mouse brain and neurological disease microenvironment with a 42-marker high-plex spatial proteomics panel. The panel enables spatial characterization of neuronal populations, neurodegenerative disease-associated proteins, neuroinflammation, immune cell infiltration, neuroplasticity, myelination, and blood-brain barrier components in mouse FFPE tissue.
Markers:
Neuronal Cell Type Markers
Mature Neurons — NeuN, MAP2, Neurofilament, Synaptophysin
GABAergic Neurons — GABA
Cholinergic Neurons — CHAT
Serotonergic Neurons — Serotonin
Neuroinflammation and Immune Response
Microglia — TMEM119
Activated Microglia and Macrophages — Iba1, CD68, Mac-2/Galectin-3, CD11b, F4/80, CD206
T Cell Infiltration — CD3e, CD4, CD8
General Immune Activation — CD44, CD45, CD20, MHC II, Ter119
Astrocyte-Associated Inflammation — GFAP
Neurodegenerative Disease Markers
Alzheimer’s Disease — Amyloid-beta, APOE, Tau (phospho T181), Tau (phospho T231), Tau (phospho S396), Tau (phospho T205)
Parkinson’s Disease and Synucleinopathies — Alpha-synuclein
General Neurodegeneration — H2A.X
Neuroplasticity and Cellular Remodeling
Proliferation and Neurogenesis — Ki67, PCNA
Astrocyte and Structural Plasticity — S100B, Vimentin
Oligodendrocytes and Myelination — MBP, Olig-2
Blood-Brain Barrier Integrity and Vascular Components
Endothelial Cells and Vascular Structure — CD31, Claudin-5, Col1A1
Pericytes and Smooth Muscle Cells — SMA
Astrocyte-Endothelial Interactions — AQP4
Analysis (Indica Halo):
NEAREST NEIGHBOR ANALYSIS
PROXIMITY ANALYSIS
INFILTRATION ANALYSIS
DENSITY HEATMAP
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